Drug interactions
Ketamine + Ribociclib
Severity: Moderate
Ketamine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and ketamine is partly cleared by CYP3A4 and CYP2B6. Exposure to ketamine may rise, increasing sedation, dissociative effects and hemodynamic changes. The effect is likely modest, particularly with single anesthetic doses.
What this interaction means in plain words
Ketamine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated N-demethylation of ketamine, reducing its clearance.
What to do
Monitor sedation depth, blood pressure and emergence reactions, and consider using lower or titrated ketamine doses in patients taking ribociclib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ketamine with Ribociclib?
MediHelp rates the interaction as moderate. Ketamine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and ketamine is partly cleared by CYP3A4 and CYP2B6. Exposure to ketamine may rise, increasing sedation, dissociative effects and hemodynamic changes. The effect is likely modest, particularly with single anesthetic doses.
How serious is the interaction between Ketamine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation depth, blood pressure and emergence reactions, and consider using lower or titrated ketamine doses in patients taking ribociclib.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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