Drug interactions
Ketamine + Tazemetostat
Severity: Minor
Ketamine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer, so it may slightly reduce exposure to CYP3A4 substrates such as ketamine. The effect is likely small and of limited clinical importance.
What this interaction means in plain words
Ketamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketamine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, modestly increasing ketamine metabolism.
What to do
Monitor analgesic or anesthetic response and adjust ketamine dose to effect. No pre-emptive change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ketamine with Tazemetostat?
MediHelp rates the interaction as minor. Ketamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer, so it may slightly reduce exposure to CYP3A4 substrates such as ketamine. The effect is likely small and of limited clinical importance.
How serious is the interaction between Ketamine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic or anesthetic response and adjust ketamine dose to effect. No pre-emptive change is needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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