Drug interactions
Ketamine + Tipranavir
Severity: Moderate
Ketamine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir is a net strong CYP3A4 inhibitor, though it also has inducing properties. Ketamine exposure may be altered, most likely increased, which could prolong sedation and enhance cardiovascular effects.
What this interaction means in plain words
Ketamine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir exerts mixed CYP3A4 inhibition and induction, altering ketamine clearance.
What to do
Titrate ketamine to effect with conservative initial dosing and monitor sedation and hemodynamics. Take extra care with oral ketamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Ketamine with Tipranavir?
MediHelp rates the interaction as moderate. Ketamine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir given with ritonavir is a net strong CYP3A4 inhibitor, though it also has inducing properties. Ketamine exposure may be altered, most likely increased, which could prolong sedation and enhance cardiovascular effects.
How serious is the interaction between Ketamine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect with conservative initial dosing and monitor sedation and hemodynamics. Take extra care with oral ketamine.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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