Drug interactions
Ketanserin + Tizanidine
Severity: Moderate
Ketanserin and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketanserin is a serotonin 5-HT2 and alpha-1 antagonist with antihypertensive effects. Combined with tizanidine it may produce additive hypotension. Ketanserin can also prolong the QT interval, which is unrelated to tizanidine's main effects but relevant to overall risk.
What this interaction means in plain words
Ketanserin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-1 and 5-HT2 antagonism with central alpha-2 agonism.
What to do
Monitor blood pressure and orthostatic symptoms. Reduce the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Ketanserin with Tizanidine?
MediHelp rates the interaction as moderate. Ketanserin and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketanserin is a serotonin 5-HT2 and alpha-1 antagonist with antihypertensive effects. Combined with tizanidine it may produce additive hypotension. Ketanserin can also prolong the QT interval, which is unrelated to tizanidine's main effects but relevant to overall risk.
How serious is the interaction between Ketanserin and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms. Reduce the dose of either drug if hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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