Drug interactions
Ketoconazole + Leniolisib
Severity: Major
Ketoconazole and Leniolisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises leniolisib exposure, which may increase dose-related adverse effects.
What this interaction means in plain words
Ketoconazole and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Leniolisib belongs to Miscellaneous.
Why it happens
Strong CYP3A4 inhibition by ketoconazole reduces leniolisib metabolism.
What to do
Avoid strong CYP3A inhibitors and select an alternative antifungal. If unavoidable, monitor for leniolisib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Ketoconazole with Leniolisib?
MediHelp rates the interaction as major. Ketoconazole and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole raises leniolisib exposure, which may increase dose-related adverse effects.
How serious is the interaction between Ketoconazole and Leniolisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inhibitors and select an alternative antifungal. If unavoidable, monitor for leniolisib adverse effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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