Drug interactions
Ketoconazole + Lesinurad
Severity: Minor
Ketoconazole and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly raise lesinurad exposure through inhibition of its metabolism. The effect is of uncertain clinical significance but could increase renal adverse effects.
What this interaction means in plain words
Ketoconazole and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Lesinurad belongs to Genitourinary.
Why it happens
Ketoconazole inhibits CYP enzymes including CYP2C9, though it is a weaker CYP2C9 inhibitor than fluconazole.
What to do
Monitor renal function during coadministration. No empirical dose change is generally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Lesinurad?
MediHelp rates the interaction as minor. Ketoconazole and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly raise lesinurad exposure through inhibition of its metabolism. The effect is of uncertain clinical significance but could increase renal adverse effects.
How serious is the interaction between Ketoconazole and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function during coadministration. No empirical dose change is generally required.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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