Drug interactions
Ketoconazole + Linagliptin-metformin
Severity: Minor
Ketoconazole and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits CYP3A4 and P-glycoprotein and increases linagliptin exposure. Linagliptin has a wide safety margin, so the clinical impact is generally small.
What this interaction means in plain words
Ketoconazole and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Linagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces linagliptin clearance.
What to do
No dose adjustment is usually required. Monitor for hypoglycemia if other glucose-lowering drugs are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Linagliptin-metformin?
MediHelp rates the interaction as minor. Ketoconazole and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole inhibits CYP3A4 and P-glycoprotein and increases linagliptin exposure. Linagliptin has a wide safety margin, so the clinical impact is generally small.
How serious is the interaction between Ketoconazole and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for hypoglycemia if other glucose-lowering drugs are also used.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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