Drug interactions
Ketoconazole + Oliceridine
Severity: Major
Ketoconazole and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits CYP3A4 and may impair CYP2D6 clearance routes of oliceridine, increasing opioid exposure. This may lead to respiratory depression and sedation, and stopping the inhibitor later can reduce opioid effect.
What this interaction means in plain words
Ketoconazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Oliceridine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2D6) reduces oliceridine metabolism.
What to do
Monitor closely for respiratory depression and sedation, dose less often and titrate carefully; reassess the dose when the inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Ketoconazole with Oliceridine?
MediHelp rates the interaction as major. Ketoconazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole inhibits CYP3A4 and may impair CYP2D6 clearance routes of oliceridine, increasing opioid exposure. This may lead to respiratory depression and sedation, and stopping the inhibitor later can reduce opioid effect.
How serious is the interaction between Ketoconazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation, dose less often and titrate carefully; reassess the dose when the inhibitor is stopped.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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