Drug interactions
Ketoconazole + Saxagliptin-metformin
Severity: Moderate
Ketoconazole and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and markedly increases saxagliptin exposure. Higher saxagliptin levels may increase the risk of adverse effects.
What this interaction means in plain words
Ketoconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4/5-mediated saxagliptin metabolism.
What to do
Limit saxagliptin to 2.5 mg daily during ketoconazole therapy; with the fixed-dose combination, switch to separate components to allow this dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ketoconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and markedly increases saxagliptin exposure. Higher saxagliptin levels may increase the risk of adverse effects.
How serious is the interaction between Ketoconazole and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily during ketoconazole therapy; with the fixed-dose combination, switch to separate components to allow this dose.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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