Drug interactions
Ketoconazole + Sparsentan
Severity: Major
Ketoconazole and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 substrate, so strong inhibitors such as ketoconazole are expected to increase its exposure and the risk of hepatotoxicity, hypotension and fluid retention.
What this interaction means in plain words
Ketoconazole and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Sparsentan belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 metabolism of sparsentan leading to higher plasma levels.
What to do
Avoid combining; if a strong CYP3A4 inhibitor is needed, interrupt sparsentan and consider re-titration afterwards, with monitoring of liver tests and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ketoconazole with Sparsentan?
MediHelp rates the interaction as major. Ketoconazole and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan is a CYP3A4 substrate, so strong inhibitors such as ketoconazole are expected to increase its exposure and the risk of hepatotoxicity, hypotension and fluid retention.
How serious is the interaction between Ketoconazole and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; if a strong CYP3A4 inhibitor is needed, interrupt sparsentan and consider re-titration afterwards, with monitoring of liver tests and blood pressure.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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