Drug interactions
Ketoconazole + Umeclidinium-vilanterol
Severity: Moderate
Ketoconazole and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and increases systemic vilanterol exposure. This may enhance cardiovascular effects such as tachycardia, QTc prolongation and hypokalemia.
What this interaction means in plain words
Ketoconazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Strong CYP3A4 and P-gp inhibition reduces vilanterol clearance and raises its systemic levels.
What to do
Use with caution and monitor for heart rate, palpitations, QTc and potassium changes. Consider an alternative antifungal or bronchodilator if cardiovascular effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ketoconazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and increases systemic vilanterol exposure. This may enhance cardiovascular effects such as tachycardia, QTc prolongation and hypokalemia.
How serious is the interaction between Ketoconazole and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with caution and monitor for heart rate, palpitations, QTc and potassium changes. Consider an alternative antifungal or bronchodilator if cardiovascular effects appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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