Drug interactions
Ketoprofen + Naproxen
Severity: Major
Ketoprofen and Naproxen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs gives no added benefit and increases the risk of gastrointestinal bleeding, renal impairment and cardiovascular events. It is regarded as duplicate therapy.
What this interaction means in plain words
Ketoprofen and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Naproxen belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition with combined platelet inhibition and loss of mucosal and renal prostaglandin protection.
What to do
Avoid concurrent use and choose a single NSAID at the lowest effective dose. Add a proton pump inhibitor if gastrointestinal risk is elevated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Ketoprofen with Naproxen?
MediHelp rates the interaction as major. Ketoprofen and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs gives no added benefit and increases the risk of gastrointestinal bleeding, renal impairment and cardiovascular events. It is regarded as duplicate therapy.
How serious is the interaction between Ketoprofen and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single NSAID at the lowest effective dose. Add a proton pump inhibitor if gastrointestinal risk is elevated.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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