Drug interactions
Ketoprofen + Ofloxacin
Severity: Moderate
Ketoprofen and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones lower the seizure threshold, and some NSAIDs may increase this effect. Seizures are uncommon but can be serious, and risk is higher with predisposing factors such as epilepsy, renal impairment or high doses.
What this interaction means in plain words
Ketoprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, which NSAIDs may potentiate; the exact mechanism is not fully established.
What to do
Avoid the combination in patients with seizure disorders or other seizure risk factors, and use an alternative analgesic or antibiotic where possible. Counsel patients to seek care for tremor, confusion or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ketoprofen with Ofloxacin?
MediHelp rates the interaction as moderate. Ketoprofen and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones lower the seizure threshold, and some NSAIDs may increase this effect. Seizures are uncommon but can be serious, and risk is higher with predisposing factors such as epilepsy, renal impairment or high doses.
How serious is the interaction between Ketoprofen and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other seizure risk factors, and use an alternative analgesic or antibiotic where possible. Counsel patients to seek care for tremor, confusion or seizures.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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