Drug interactions
Ketoprofen + Paroxetine
Severity: Moderate
Ketoprofen and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination of an SSRI and an NSAID increases the risk of upper gastrointestinal bleeding well beyond that of either drug alone. Risk is higher in older adults and those with prior ulcer disease.
What this interaction means in plain words
Ketoprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation while NSAIDs inhibit platelet thromboxane and damage gastric mucosa, giving additive bleeding risk.
What to do
Where possible avoid long-term co-use; otherwise add a proton pump inhibitor and counsel patients to report black stools or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoprofen and Paroxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Ketoprofen with Paroxetine?
MediHelp rates the interaction as moderate. Ketoprofen and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination of an SSRI and an NSAID increases the risk of upper gastrointestinal bleeding well beyond that of either drug alone. Risk is higher in older adults and those with prior ulcer disease.
How serious is the interaction between Ketoprofen and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid long-term co-use; otherwise add a proton pump inhibitor and counsel patients to report black stools or hematemesis.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
