Drug interactions
Ketoprofen + Prednisolone
Severity: Moderate
Ketoprofen and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastric irritation, ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with higher doses and with longer duration.
What this interaction means in plain words
Ketoprofen and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury: NSAIDs inhibit protective prostaglandins while corticosteroids impair mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Prednisolone?
MediHelp rates the interaction as moderate. Ketoprofen and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastric irritation, ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with higher doses and with longer duration.
How serious is the interaction between Ketoprofen and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or abdominal pain.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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