Drug interactions
Ketoprofen + Spironolactone
Severity: Major
Ketoprofen and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can reduce the diuretic and antihypertensive effects of spironolactone and increase the risk of hyperkalemia and acute kidney injury. Risk is highest in elderly patients, those with heart failure or renal impairment, or on ACE inhibitors.
What this interaction means in plain words
Ketoprofen and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and aldosterone-renin signaling, adding to aldosterone antagonism and potassium retention.
What to do
Avoid regular NSAID use in at-risk patients; otherwise monitor serum potassium, creatinine and blood pressure after starting and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Ketoprofen with Spironolactone?
MediHelp rates the interaction as major. Ketoprofen and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoprofen can reduce the diuretic and antihypertensive effects of spironolactone and increase the risk of hyperkalemia and acute kidney injury. Risk is highest in elderly patients, those with heart failure or renal impairment, or on ACE inhibitors.
How serious is the interaction between Ketoprofen and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in at-risk patients; otherwise monitor serum potassium, creatinine and blood pressure after starting and periodically.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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