Drug interactions
Ketoprofen + Streptomycin
Severity: Moderate
Ketoprofen and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce glomerular filtration and slow aminoglycoside excretion, leading to higher drug levels. The effect has been described mainly in neonates and risks nephrotoxicity and ototoxicity. Data specific to ketoprofen are limited.
What this interaction means in plain words
Ketoprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal perfusion and glomerular filtration decreases aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor renal function and streptomycin serum concentrations, and watch for vestibular or auditory symptoms. Adjust the streptomycin dose according to levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoprofen and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Ketoprofen with Streptomycin?
MediHelp rates the interaction as moderate. Ketoprofen and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce glomerular filtration and slow aminoglycoside excretion, leading to higher drug levels. The effect has been described mainly in neonates and risks nephrotoxicity and ototoxicity. Data specific to ketoprofen are limited.
How serious is the interaction between Ketoprofen and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin serum concentrations, and watch for vestibular or auditory symptoms. Adjust the streptomycin dose according to levels and renal function.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
