Drug interactions
Ketoprofen + Tobramycin
Severity: Moderate
Ketoprofen and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of aminoglycosides, raising tobramycin concentrations. This is described mainly in preterm infants, and both drug classes are nephrotoxic, so kidney injury and ototoxicity become more likely.
What this interaction means in plain words
Ketoprofen and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID-mediated reduction in renal blood flow and filtration lowers aminoglycoside elimination, with additive nephrotoxicity.
What to do
Monitor tobramycin peak and trough levels and serum creatinine during combined use. Adjust the tobramycin dose accordingly or select an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Ketoprofen with Tobramycin?
MediHelp rates the interaction as moderate. Ketoprofen and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of aminoglycosides, raising tobramycin concentrations. This is described mainly in preterm infants, and both drug classes are nephrotoxic, so kidney injury and ototoxicity become more likely.
How serious is the interaction between Ketoprofen and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin peak and trough levels and serum creatinine during combined use. Adjust the tobramycin dose accordingly or select an alternative analgesic.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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