Drug interactions
Ketoprofen + Tolmetin
Severity: Major
Ketoprofen and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together increases the likelihood of gastrointestinal bleeding, ulceration and kidney injury without improving pain relief. Platelet inhibition from both drugs is additive.
What this interaction means in plain words
Ketoprofen and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoprofen belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive non-selective COX inhibition reduces protective prostaglandins in the gut and kidney and impairs platelet function.
What to do
Avoid combining the two; keep a single NSAID at the lowest effective dose. Add gastroprotection and monitor renal function if therapy overlap cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Ketoprofen with Tolmetin?
MediHelp rates the interaction as major. Ketoprofen and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two NSAIDs together increases the likelihood of gastrointestinal bleeding, ulceration and kidney injury without improving pain relief. Platelet inhibition from both drugs is additive.
How serious is the interaction between Ketoprofen and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; keep a single NSAID at the lowest effective dose. Add gastroprotection and monitor renal function if therapy overlap cannot be avoided.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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