Drug interactions
Ketoprofen + Trandolapril
Severity: Moderate
Ketoprofen and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can blunt the blood pressure lowering effect of trandolapril and may reduce kidney function, especially in older, volume-depleted or renally impaired patients. The risk of acute kidney injury and hyperkalemia is increased.
What this interaction means in plain words
Ketoprofen and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Trandolapril belongs to Cardiovascular.
Why it happens
NSAID inhibition of cyclooxygenase reduces renal vasodilatory prostaglandins and sodium excretion, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Ketoprofen with Trandolapril?
MediHelp rates the interaction as moderate. Ketoprofen and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can blunt the blood pressure lowering effect of trandolapril and may reduce kidney function, especially in older, volume-depleted or renally impaired patients. The risk of acute kidney injury and hyperkalemia is increased.
How serious is the interaction between Ketoprofen and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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