Drug interactions
Ketoprofen + Valganciclovir
Severity: Moderate
Ketoprofen and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which is renally eliminated partly by tubular secretion. Ketoprofen may compete for this pathway and can also reduce renal function, potentially raising ganciclovir exposure and toxicity.
What this interaction means in plain words
Ketoprofen and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal function decrease ganciclovir clearance.
What to do
Monitor renal function and complete blood counts, and dose valganciclovir to creatinine clearance. Avoid NSAIDs in patients with impaired renal function where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Ketoprofen with Valganciclovir?
MediHelp rates the interaction as moderate. Ketoprofen and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valganciclovir is converted to ganciclovir, which is renally eliminated partly by tubular secretion. Ketoprofen may compete for this pathway and can also reduce renal function, potentially raising ganciclovir exposure and toxicity.
How serious is the interaction between Ketoprofen and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and complete blood counts, and dose valganciclovir to creatinine clearance. Avoid NSAIDs in patients with impaired renal function where possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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