Drug interactions
Ketorolac + Levomilnacipran
Severity: Moderate
Ketorolac and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs reduce platelet serotonin content and impair aggregation, which raises bleeding risk. Combined with ketorolac, the risk of gastrointestinal and other bleeding is increased.
What this interaction means in plain words
Ketorolac and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and COX-1 inhibition, plus NSAID gastric mucosal injury.
What to do
Avoid prolonged coadministration where possible and monitor for bleeding. Consider gastroprotection in patients with GI risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Ketorolac with Levomilnacipran?
MediHelp rates the interaction as moderate. Ketorolac and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs reduce platelet serotonin content and impair aggregation, which raises bleeding risk. Combined with ketorolac, the risk of gastrointestinal and other bleeding is increased.
How serious is the interaction between Ketorolac and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration where possible and monitor for bleeding. Consider gastroprotection in patients with GI risk factors.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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