Drug interactions
Ketorolac + Losartan
Severity: Major
Ketorolac and Losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the antihypertensive effect of losartan and, together with an angiotensin receptor blocker, may cause acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Ketorolac and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAID blockade of vasodilatory prostaglandins reduces glomerular perfusion, which ARB-mediated efferent dilation cannot compensate for, and both impair potassium excretion.
What to do
Avoid or minimize ketorolac use and keep the patient well hydrated. Monitor blood pressure, serum creatinine, and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Ketorolac with Losartan?
MediHelp rates the interaction as major. Ketorolac and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac can reduce the antihypertensive effect of losartan and, together with an angiotensin receptor blocker, may cause acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Ketorolac and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize ketorolac use and keep the patient well hydrated. Monitor blood pressure, serum creatinine, and potassium.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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