Drug interactions
Ketorolac + Moxifloxacin
Severity: Moderate
Ketorolac and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulation and seizure risk associated with fluoroquinolones. Susceptible patients include those with epilepsy, CNS disease or renal impairment.
What this interaction means in plain words
Ketorolac and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid the combination in patients with seizure risk factors; otherwise monitor for agitation, tremor or seizures and use the shortest ketorolac course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Ketorolac with Moxifloxacin?
MediHelp rates the interaction as moderate. Ketorolac and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulation and seizure risk associated with fluoroquinolones. Susceptible patients include those with epilepsy, CNS disease or renal impairment.
How serious is the interaction between Ketorolac and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure risk factors; otherwise monitor for agitation, tremor or seizures and use the shortest ketorolac course.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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