Drug interactions
Ketorolac + Mycophenolate mofetil
Severity: Moderate
Ketorolac and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac may compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise exposure. It also adds gastrointestinal bleeding and nephrotoxicity risk, which is a particular concern in transplant patients.
What this interaction means in plain words
Ketorolac and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide, plus additive gastrointestinal and renal toxicity.
What to do
Avoid prolonged ketorolac use and keep courses short. Monitor renal function, blood counts and gastrointestinal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Ketorolac and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac may compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise exposure. It also adds gastrointestinal bleeding and nephrotoxicity risk, which is a particular concern in transplant patients.
How serious is the interaction between Ketorolac and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged ketorolac use and keep courses short. Monitor renal function, blood counts and gastrointestinal symptoms.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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