Drug interactions
Ketorolac + Succinylcholine
Severity: Minor
Ketorolac and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established clinically meaningful interaction exists. Hyperkalemia is a recognized effect of succinylcholine, but ketorolac is rarely a significant contributor in patients with normal renal function.
What this interaction means in plain words
Ketorolac and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketorolac belongs to Musculoskeletal; Succinylcholine belongs to Musculoskeletal.
Why it happens
Possible additive potassium elevation, since NSAIDs can reduce renal potassium excretion while succinylcholine releases potassium from muscle; the effect is small.
What to do
Monitor serum potassium perioperatively in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Succinylcholine
Frequently asked questions
Can I take Ketorolac with Succinylcholine?
MediHelp rates the interaction as minor. Ketorolac and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established clinically meaningful interaction exists. Hyperkalemia is a recognized effect of succinylcholine, but ketorolac is rarely a significant contributor in patients with normal renal function.
How serious is the interaction between Ketorolac and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium perioperatively in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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