Drug interactions
Ketorolac + Torsemide
Severity: Moderate
Ketorolac and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ketorolac can reduce the diuretic and natriuretic response to loop diuretics and may worsen renal function, especially in volume-depleted patients. Fluid retention or reduced antihypertensive effect can result.
What this interaction means in plain words
Ketorolac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, blunting loop diuretic action.
What to do
Monitor weight, fluid status, blood pressure and creatinine; avoid ketorolac in dehydrated patients and increase the diuretic dose only if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Torsemide
Frequently asked questions
Can I take Ketorolac with Torsemide?
MediHelp rates the interaction as moderate. Ketorolac and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ketorolac can reduce the diuretic and natriuretic response to loop diuretics and may worsen renal function, especially in volume-depleted patients. Fluid retention or reduced antihypertensive effect can result.
How serious is the interaction between Ketorolac and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, fluid status, blood pressure and creatinine; avoid ketorolac in dehydrated patients and increase the diuretic dose only if needed.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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