Drug interactions
Ketorolac intranasal + Metoprolol
Severity: Moderate
Ketorolac intranasal and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID that can reduce the antihypertensive effect of beta-blockers, particularly with prolonged use. NSAIDs also add renal risk in susceptible patients.
What this interaction means in plain words
Ketorolac intranasal and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and fluid retention and reduced vasodilation.
What to do
Limit ketorolac to short courses and monitor blood pressure if used beyond a few days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Ketorolac intranasal with Metoprolol?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is an NSAID that can reduce the antihypertensive effect of beta-blockers, particularly with prolonged use. NSAIDs also add renal risk in susceptible patients.
How serious is the interaction between Ketorolac intranasal and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to short courses and monitor blood pressure if used beyond a few days.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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