Drug interactions
Ketorolac intranasal + Moxifloxacin
Severity: Minor
Ketorolac intranasal and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs given with fluoroquinolones have been associated with increased CNS stimulation and seizures. With intranasal ketorolac, systemic exposure is lower, so the risk is probably small but not nil.
What this interaction means in plain words
Ketorolac intranasal and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors, which may be enhanced by NSAIDs; the mechanism is not fully established.
What to do
No routine change is needed; watch for tremor, agitation or seizures, especially in patients with epilepsy or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Moxifloxacin?
MediHelp rates the interaction as minor. Ketorolac intranasal and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs given with fluoroquinolones have been associated with increased CNS stimulation and seizures. With intranasal ketorolac, systemic exposure is lower, so the risk is probably small but not nil.
How serious is the interaction between Ketorolac intranasal and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for tremor, agitation or seizures, especially in patients with epilepsy or renal impairment.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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