Drug interactions
Ketorolac intranasal + Mycophenolate mofetil
Severity: Minor
Ketorolac intranasal and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac and the mycophenolic acid glucuronide metabolite are both acidic and may compete for renal tubular secretion. This could modestly raise mycophenolate metabolite levels. Intranasal dosing gives limited exposure, and the clinical significance is uncertain.
What this interaction means in plain words
Ketorolac intranasal and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide by an acidic drug.
What to do
No routine adjustment is needed; monitor blood counts and renal function. Ketorolac also carries nephrotoxic risk, so limit duration of use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac intranasal and Mycophenolate mofetil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Ketorolac intranasal and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketorolac and the mycophenolic acid glucuronide metabolite are both acidic and may compete for renal tubular secretion. This could modestly raise mycophenolate metabolite levels. Intranasal dosing gives limited exposure, and the clinical significance is uncertain.
How serious is the interaction between Ketorolac intranasal and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts and renal function. Ketorolac also carries nephrotoxic risk, so limit duration of use.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
