Drug interactions
Ketotifen + Sufentanil
Severity: Moderate
Ketotifen and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid that causes sedation and respiratory depression, and ketotifen is a sedating antihistamine. Together they may deepen sedation and add to central nervous system depression.
What this interaction means in plain words
Ketotifen and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketotifen belongs to Respiratory; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from opioid receptor agonism and H1-antihistamine activity.
What to do
Monitor sedation level and respiratory status when both are used, and reduce opioid dosing if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketotifen and Sufentanil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Ketotifen with Sufentanil?
MediHelp rates the interaction as moderate. Ketotifen and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid that causes sedation and respiratory depression, and ketotifen is a sedating antihistamine. Together they may deepen sedation and add to central nervous system depression.
How serious is the interaction between Ketotifen and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status when both are used, and reduce opioid dosing if excessive sedation occurs.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
