Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + L-methylfolate
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may slightly increase urinary folate loss. Clinically relevant deficiency is unlikely in patients with adequate intake.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Increased renal excretion of folate during diuresis; the mechanism is not firmly established.
What to do
No routine action is needed; assess folate status if deficiency is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with L-methylfolate?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may slightly increase urinary folate loss. Clinically relevant deficiency is unlikely in patients with adequate intake.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; assess folate status if deficiency is suspected.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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