Drug interactions
Labetalol + Levobetaxolol
Severity: Moderate
Labetalol and Levobetaxolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levobetaxolol is an ophthalmic beta blocker that is partly absorbed systemically, and it may add to the beta blocking effects of oral labetalol. This can lead to bradycardia, hypotension or bronchospasm in susceptible patients.
What this interaction means in plain words
Labetalol and Levobetaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade from systemic absorption of the ophthalmic agent.
What to do
Monitor heart rate and blood pressure, and watch for respiratory symptoms in patients with airway disease. Consider a non-beta-blocker glaucoma agent if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Levobetaxolol?
MediHelp rates the interaction as moderate. Labetalol and Levobetaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levobetaxolol is an ophthalmic beta blocker that is partly absorbed systemically, and it may add to the beta blocking effects of oral labetalol. This can lead to bradycardia, hypotension or bronchospasm in susceptible patients.
How serious is the interaction between Labetalol and Levobetaxolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and watch for respiratory symptoms in patients with airway disease. Consider a non-beta-blocker glaucoma agent if effects occur.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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