Drug interactions
Labetalol + Meclofenamate
Severity: Moderate
Labetalol and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate and other NSAIDs can reduce the antihypertensive effect of labetalol with regular use. Fluid retention and renal effects may worsen blood pressure control.
What this interaction means in plain words
Labetalol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis causes sodium and fluid retention, counteracting labetalol.
What to do
Monitor blood pressure during regular NSAID therapy and use the lowest effective dose for the shortest period. Consider paracetamol or another alternative if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Meclofenamate?
MediHelp rates the interaction as moderate. Labetalol and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate and other NSAIDs can reduce the antihypertensive effect of labetalol with regular use. Fluid retention and renal effects may worsen blood pressure control.
How serious is the interaction between Labetalol and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during regular NSAID therapy and use the lowest effective dose for the shortest period. Consider paracetamol or another alternative if control worsens.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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