Drug interactions
Labetalol + Metaproterenol
Severity: Major
Labetalol and Metaproterenol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta receptors and can reduce the bronchodilator effect of metaproterenol. In patients with reactive airway disease this may lead to bronchospasm and poor response to the beta-agonist.
What this interaction means in plain words
Labetalol and Metaproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Labetalol's beta-2 antagonism competes with metaproterenol's agonist action at bronchial receptors.
What to do
Avoid combining in patients with asthma or COPD where possible and choose a different antihypertensive. If unavoidable, monitor respiratory function and bronchodilator response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Labetalol and Metaproterenol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Metaproterenol?
MediHelp rates the interaction as major. Labetalol and Metaproterenol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta receptors and can reduce the bronchodilator effect of metaproterenol. In patients with reactive airway disease this may lead to bronchospasm and poor response to the beta-agonist.
How serious is the interaction between Labetalol and Metaproterenol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in patients with asthma or COPD where possible and choose a different antihypertensive. If unavoidable, monitor respiratory function and bronchodilator response.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
