Drug interactions
Labetalol + Metipranolol
Severity: Moderate
Labetalol and Metipranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metipranolol eye drops are a beta blocker with some systemic absorption, which may add to the beta blockade from labetalol. This can result in bradycardia, hypotension or bronchospasm in susceptible patients.
What this interaction means in plain words
Labetalol and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic blockade through systemic absorption of the ophthalmic drug.
What to do
Monitor heart rate and blood pressure, and ask about wheeze or breathlessness. Consider a non-beta-blocker glaucoma treatment if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Metipranolol?
MediHelp rates the interaction as moderate. Labetalol and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metipranolol eye drops are a beta blocker with some systemic absorption, which may add to the beta blockade from labetalol. This can result in bradycardia, hypotension or bronchospasm in susceptible patients.
How serious is the interaction between Labetalol and Metipranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and ask about wheeze or breathlessness. Consider a non-beta-blocker glaucoma treatment if symptoms occur.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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