Drug interactions
Labetalol + Mipomersen
Severity: Moderate
Labetalol and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause elevated transaminases and hepatic fat accumulation, and labetalol is also occasionally associated with liver injury. Using them together may theoretically increase the risk of hepatotoxicity.
What this interaction means in plain words
Labetalol and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatotoxicity; no specific pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin at baseline and regularly during mipomersen therapy. Stop the suspected agent if significant hepatic abnormalities arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Mipomersen?
MediHelp rates the interaction as moderate. Labetalol and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause elevated transaminases and hepatic fat accumulation, and labetalol is also occasionally associated with liver injury. Using them together may theoretically increase the risk of hepatotoxicity.
How serious is the interaction between Labetalol and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin at baseline and regularly during mipomersen therapy. Stop the suspected agent if significant hepatic abnormalities arise.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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