Drug interactions
Labetalol + Olanzapine / samidorphan
Severity: Moderate
Labetalol and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of labetalol. Patients may experience dizziness, syncope or falls, particularly early in treatment or after dose increases.
What this interaction means in plain words
Labetalol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from olanzapine alpha-1 adrenergic antagonism combined with labetalol alpha/beta blockade.
What to do
Monitor blood pressure, including orthostatic readings, when starting or adjusting either drug. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Labetalol and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of labetalol. Patients may experience dizziness, syncope or falls, particularly early in treatment or after dose increases.
How serious is the interaction between Labetalol and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when starting or adjusting either drug. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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