Drug interactions
Labetalol + Olodaterol inhaled
Severity: Major
Labetalol and Olodaterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-2 receptors and can oppose the bronchodilation produced by olodaterol. In patients with COPD or asthma this may cause bronchospasm and reduced benefit from the inhaler.
What this interaction means in plain words
Labetalol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Beta-adrenergic antagonism by labetalol competes with olodaterol at beta-2 receptors.
What to do
Avoid non-selective beta-blockers like labetalol in COPD or asthma where possible, using a cardioselective agent if a beta-blocker is essential. Monitor lung function and symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Olodaterol inhaled?
MediHelp rates the interaction as major. Labetalol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta-2 receptors and can oppose the bronchodilation produced by olodaterol. In patients with COPD or asthma this may cause bronchospasm and reduced benefit from the inhaler.
How serious is the interaction between Labetalol and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers like labetalol in COPD or asthma where possible, using a cardioselective agent if a beta-blocker is essential. Monitor lung function and symptoms.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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