Drug interactions
Labetalol + Pindolol
Severity: Moderate
Labetalol and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-blockers, and combining them duplicates therapy with additive hypotension and bradycardia. Pindolol's partial agonist activity may further blunt the intended effect of the other agent.
What this interaction means in plain words
Labetalol and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-blockade, with pindolol's intrinsic sympathomimetic activity partially opposing labetalol.
What to do
Avoid duplicate beta-blockade and use a single agent. If both are given, monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Labetalol and Pindolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Pindolol?
MediHelp rates the interaction as moderate. Labetalol and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-blockers, and combining them duplicates therapy with additive hypotension and bradycardia. Pindolol's partial agonist activity may further blunt the intended effect of the other agent.
How serious is the interaction between Labetalol and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate beta-blockade and use a single agent. If both are given, monitor heart rate and blood pressure.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
