Drug interactions
Labetalol + Pirbuterol
Severity: Moderate
Labetalol and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-adrenergic receptors and can oppose the bronchodilating action of pirbuterol. In patients with asthma or COPD, this may reduce bronchodilator response and may provoke bronchospasm.
What this interaction means in plain words
Labetalol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors; labetalol is a nonselective beta-blocker with alpha-1 blocking activity.
What to do
Avoid labetalol in patients with reactive airway disease who depend on beta-agonists, or choose a cardioselective agent if a beta-blocker is needed. Monitor respiratory status and bronchodilator response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Pirbuterol?
MediHelp rates the interaction as moderate. Labetalol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks beta-adrenergic receptors and can oppose the bronchodilating action of pirbuterol. In patients with asthma or COPD, this may reduce bronchodilator response and may provoke bronchospasm.
How serious is the interaction between Labetalol and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients with reactive airway disease who depend on beta-agonists, or choose a cardioselective agent if a beta-blocker is needed. Monitor respiratory status and bronchodilator response.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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