Drug interactions
Labetalol + Prazosin
Severity: Moderate
Labetalol and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block alpha-1 receptors, and labetalol adds beta-blockade, so blood pressure lowering is additive. Orthostatic hypotension and first-dose syncope are more likely.
What this interaction means in plain words
Labetalol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade with reduced compensatory tachycardia.
What to do
Start prazosin at a low bedtime dose and check standing blood pressure after changes. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Labetalol with Prazosin?
MediHelp rates the interaction as moderate. Labetalol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block alpha-1 receptors, and labetalol adds beta-blockade, so blood pressure lowering is additive. Orthostatic hypotension and first-dose syncope are more likely.
How serious is the interaction between Labetalol and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low bedtime dose and check standing blood pressure after changes. Counsel patients to rise slowly.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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