Drug interactions
Labetalol + Sacubitril / valsartan
Severity: Moderate
Labetalol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope, particularly at initiation or dose increases. Sacubitril/valsartan also raises potassium and affects renal function, and is contraindicated in pregnancy because of fetal toxicity.
What this interaction means in plain words
Labetalol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive pharmacodynamic effects; the angiotensin receptor blocker component also reduces aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, serum potassium and renal function after initiation and dose changes. Confirm patients are not pregnant and counsel women of childbearing potential on contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Labetalol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use can cause additive hypotension, dizziness or syncope, particularly at initiation or dose increases. Sacubitril/valsartan also raises potassium and affects renal function, and is contraindicated in pregnancy because of fetal toxicity.
How serious is the interaction between Labetalol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and renal function after initiation and dose changes. Confirm patients are not pregnant and counsel women of childbearing potential on contraception.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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