Drug interactions
Labetalol + Salsalate
Severity: Minor
Labetalol and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with weak prostaglandin inhibition, so any blunting of labetalol's blood pressure effect is likely small. Long-term use or renal impairment may increase the likelihood of an effect.
What this interaction means in plain words
Labetalol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced renal prostaglandin synthesis may cause mild sodium and water retention opposing labetalol's effect.
What to do
Monitor blood pressure during prolonged salsalate therapy and adjust labetalol if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Salsalate?
MediHelp rates the interaction as minor. Labetalol and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is a non-acetylated salicylate with weak prostaglandin inhibition, so any blunting of labetalol's blood pressure effect is likely small. Long-term use or renal impairment may increase the likelihood of an effect.
How serious is the interaction between Labetalol and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during prolonged salsalate therapy and adjust labetalol if control is lost.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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