Drug interactions
Labetalol + Sildenafil
Severity: Moderate
Labetalol and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks alpha-1 and beta receptors and lowers blood pressure, while sildenafil causes vasodilation. Combined use can cause additive hypotension and orthostatic symptoms.
What this interaction means in plain words
Labetalol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and combined alpha/beta-adrenergic blockade.
What to do
Start sildenafil at the lowest dose and monitor blood pressure and postural symptoms. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Sildenafil?
MediHelp rates the interaction as moderate. Labetalol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks alpha-1 and beta receptors and lowers blood pressure, while sildenafil causes vasodilation. Combined use can cause additive hypotension and orthostatic symptoms.
How serious is the interaction between Labetalol and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at the lowest dose and monitor blood pressure and postural symptoms. Counsel patients to rise slowly.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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