Drug interactions
Labetalol + Sodium citrate / citric acid
Severity: Minor
Labetalol and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sodium citrate/citric acid may lower labetalol absorption through its antacid effect, which could slightly reduce efficacy. The effect is likely small and avoidable with spacing.
What this interaction means in plain words
Labetalol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Neutralization of gastric acid may reduce oral absorption of labetalol.
What to do
Separate oral doses by about 2 hours and monitor blood pressure if used regularly together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Labetalol and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral sodium citrate/citric acid may lower labetalol absorption through its antacid effect, which could slightly reduce efficacy. The effect is likely small and avoidable with spacing.
How serious is the interaction between Labetalol and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral doses by about 2 hours and monitor blood pressure if used regularly together.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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