Drug interactions
Labetalol + Telmisartan-amlodipine
Severity: Moderate
Labetalol and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds to the blood pressure lowering effect of the telmisartan-amlodipine combination, which may cause excessive hypotension, dizziness or bradycardia. Combination antihypertensive therapy is often intentional, but the dose may need adjustment.
What this interaction means in plain words
Labetalol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through alpha/beta adrenergic blockade, angiotensin receptor blockade and calcium channel blockade.
What to do
Monitor blood pressure and heart rate when starting or titrating, and reduce doses if symptomatic hypotension occurs. Avoid use in pregnancy because of the ARB component.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Labetalol and Telmisartan-amlodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Labetalol and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol adds to the blood pressure lowering effect of the telmisartan-amlodipine combination, which may cause excessive hypotension, dizziness or bradycardia. Combination antihypertensive therapy is often intentional, but the dose may need adjustment.
How serious is the interaction between Labetalol and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating, and reduce doses if symptomatic hypotension occurs. Avoid use in pregnancy because of the ARB component.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
