Drug interactions
Labetalol + Telmisartan
Severity: Moderate
Labetalol and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with labetalol produces additive blood pressure lowering, which is often intended but can cause symptomatic hypotension. Telmisartan is also fetotoxic in pregnancy, which matters because labetalol is commonly used in pregnant patients.
What this interaction means in plain words
Labetalol and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through angiotensin receptor blockade and adrenergic blockade.
What to do
Monitor blood pressure and adjust doses, especially at initiation. Avoid telmisartan in pregnancy and stop it as soon as pregnancy is detected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Labetalol and Telmisartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Labetalol with Telmisartan?
MediHelp rates the interaction as moderate. Labetalol and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an angiotensin receptor blocker with labetalol produces additive blood pressure lowering, which is often intended but can cause symptomatic hypotension. Telmisartan is also fetotoxic in pregnancy, which matters because labetalol is commonly used in pregnant patients.
How serious is the interaction between Labetalol and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust doses, especially at initiation. Avoid telmisartan in pregnancy and stop it as soon as pregnancy is detected.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
