Drug interactions
Labetalol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Labetalol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol is a non-selective beta-blocker that can antagonize the bronchodilator effect of inhaled vilanterol and may provoke bronchospasm in patients with obstructive airway disease. The effect of the inhaled agent may be reduced.
What this interaction means in plain words
Labetalol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors in the airways.
What to do
Avoid in asthma or COPD where possible, or choose a cardioselective beta-1 blocker. If labetalol is needed, monitor lung function and symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Labetalol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol is a non-selective beta-blocker that can antagonize the bronchodilator effect of inhaled vilanterol and may provoke bronchospasm in patients with obstructive airway disease. The effect of the inhaled agent may be reduced.
How serious is the interaction between Labetalol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in asthma or COPD where possible, or choose a cardioselective beta-1 blocker. If labetalol is needed, monitor lung function and symptoms.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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