Drug interactions
Labetalol + Vilanterol / fluticasone furoate inhaled
Severity: Major
Labetalol and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-2 receptors and can oppose the bronchodilating effect of vilanterol, risking bronchospasm and loss of asthma or COPD control.
What this interaction means in plain words
Labetalol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Prefer a cardioselective beta-1 blocker in patients needing a beta-agonist. If labetalol is used, monitor respiratory symptoms and peak flow.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Labetalol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta-2 receptors and can oppose the bronchodilating effect of vilanterol, risking bronchospasm and loss of asthma or COPD control.
How serious is the interaction between Labetalol and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a cardioselective beta-1 blocker in patients needing a beta-agonist. If labetalol is used, monitor respiratory symptoms and peak flow.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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